TopicNeuro
threat memory
1 Seminar1 ePoster
Latest
SeminarNeuroscience
Top-down control of neocortical threat memory
Prof. Dr. Johannes Letzkus
Universität Freiburg, Germany
Nov 12, 2025
Accurate perception of the environment is a constructive process that requires integration of external bottom-up sensory signals with internally-generated top-down information reflecting past experiences and current aims. Decades of work have elucidated how sensory neocortex processes physical stimulus features. In contrast, examining how memory-related-top-down information is encoded and integrated with bottom-up signals has long been challenging. Here, I will discuss our recent work pinpointing the outermost layer 1 of neocortex as a central hotspot for processing of experience-dependent top-down information threat during perception, one of the most fundamentally important forms of sensation.
ePosterNeuroscience
Acute stress via retrograde endocannabinoid signaling disrupts engram ensemble specificity to generalize threat memory in mice
Sylvie Lesuis, Annelies Hoorn, Mario van der Stelt, Brandon Walters, Paul Frankland, Sheena Josselyn
FENS Forum 2024
threat memory coverage
2 items
Seminar1
ePoster1